Salvia 20x

The active principle in S. divinorum is salvinorin A, a furanolactone neoclerodane diterpenThe active principle in S. divinorum is salvinorin A, a furanolactone neoclerodane diterpene: Salvinorin A is hydrophobic, which explains a lot about the methods of dosing; an infusion is always made using fresh leaves, so that an emulsion is formed (thus giving a foamy head). Its activity and potency in open-field tests with mice are similar to mescaline: decreased activity without sedation, and no loss of righting reflex. Doses of up to 100mg/kg were tested in mice, although the method of administration was later found to be highly inefficient. It is active in humans at 200-500 micrograms, and is thus many times more potent than any other plant-based hallucinogen. Doses of 1000mg/kg in mice did not produce fatalities (this is 5000 times the effective dose for humans!)

salvia 20x A may be extracted from fresh or dried leaves (dried leaves are probably easier). Valdas et al. successfully isolated salvinorin A:

After extracting the dried leaves with ether in a Soxhlet apparatus and partitioning the extract between hexane and aqueous methanol, one has a fraction that is almost 10% salvia 20x A by weight when dried. This procedure is so effective at concentrating the diterpene that the crude compound often precipitates out of the aqueous methanol solution before being subjected to chromatography. Ether is used to extract the plant material because it has a low boiling point, but chloroform or methylene chloride will serve as well for this initial extraction. Chromatography is used for final purification of the compound because it is faster and gives higher yields than repeated recrystallization of the precipitate.

One kilogram of dried leaves produces about 1 gram of salvia 20x A (about 2000 doses).

When smoked, salvinorin A is vaporized. Any vaporization pipe should work quite well. In all the reports that I could find, the salvinorin A was placed onto a piece of aluminum foil and heated, and the vapors inhaled through a glass pipe.

Nobody knows exactly how salvorin A works. There are four general classes of hallucinogens, which all tend to act differently (q.v.). The very high pharmacological index (i.e., the ratio of lethal to effective dose) and lack of pupil dilation rule out the anticholinergics, which have a very low index (and are thus very dangerous) and dilate the pupils. The lack of significant "stoning" activity probably rules out anandimidics. This leaves two classes: 5HT and NMDA/Sigma.

The nature of the hallucinatory experiences tend, to point away from the 5HT class. salvia 20x A induces hallucinations that are not only believable, but often fully believed by the user. Furthermore, salvinorin A hallucinations tend to occur only in darkness and silence, unlike the 5HT class. However, it is entirely possible that salvinorin A may have some 5HT hallucinatory activity.

The NMDA/sigma class shares a lot in common with salvinorin A. The hallucinations tend to be eidetic at lower doses, i.e., more like vivid imagination than true hallucinations. Like salvinorin A, NMDA/sigma agents tend to be more hallucinatory in the dark and in silence. The synchronization of experiences among people who share their experiences as they have them is also a feature that has been identified in NMDA/sigma hallucinogens. The general nature of the hallucinations is also consistent with NMDA/sigma agents. Interestingly, salvinorin A does not seem to produce significant dissociative effects. Thus if it is a NMDA/sigma agent, it is probably much more potent at sigma receptors than NMDA.

We may have come across the very first natural NMDA/sigma hallucinogen. If so, its lack of dissociative effects could lead to significant improvements in our understanding of the psychophysiology of sigma receptors.

Salvia-Extract 20X

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Feature Product

All prices quoted are in United States Dollars (USD) Salvia Divinorum Extract 20x Our 20x extract is extremely rare and hard to find and contains 72mg of pure salvinorin-A per gram of extract which is extracted from the plant and then redeposited back onto dried leaves. Our skilled chemists use a standardized method, which costs a little more than non-standardized methods, but means you will find no extra plant matter which can be harmful to your lungs. Salvia Extract is not a liquid. This dosage has been described as very potent, and we recommend that you exercise caution when using this product. Experienced salvia users only. Use with caution    Salvia Divinorum Extract 20x, 1g $48.40  Salvia Divinorum Extract 20x, 3g $108.90  Salvia Divinorum Extract 20x, 10g $302.50  Salvia Divinorum Extract 20x, 25g $550.55  Salvia Divinorum Extract 20x, 50g $919.60